| 1. Round | 01/08/2022 | Real España | - | Lobos UPNFM | 1:0 | ||||
| 8. Round | 04/09/2022 | Olancho FC | - | Real España | 3:1 | ||||
| 12. Round | 08/10/2022 | Real España | - | Real Sociedad | 1:3 | ||||
| 13. Round | 16/10/2022 | Victoria | - | Real España | 1:4 | ||||
| 15. Round | 23/10/2022 | Marathón | - | Real España | 2:0 |  |
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| 17. Round | 13/11/2022 | Real España | - | Olancho FC | 4:3 | ||||
| 18. Round | 19/11/2022 | Honduras Progreso | - | Real España | 0:0 |
Honduras