| 1. Round | 23/01/2022 | Atlético Junior | - | Patriotas FC | 3:1 |  |
|||
| 7. Round | 17/02/2022 | Independiente Medellín | - | Atlético Junior | 2:0 |  |
|||
| 8. Round | 20/02/2022 | Atlético Junior | - | América de Cali | 1:0 | |
|
||
| 9. Round | 26/02/2022 | Deportes Tolima | - | Atlético Junior | 0:2 | ||||
| 10. Round | 05/03/2022 | Atlético Junior | - | Unión Magdalena | 3:1 | |
|||
| 13. Round | 31/03/2022 | Millonarios | - | Atlético Junior | 1:0 | ||||
| 14. Round | 03/04/2022 | Atlético Junior | - | Alianza Petrolera | 3:1 | |
|||
| 15. Round | 10/04/2022 | Deportivo Cali | - | Atlético Junior | 1:1 | ||||
| 16. Round | 17/04/2022 | Atlético Junior | - | Atlético Bucaramanga | 2:0 | ||||
| 18. Round | 02/05/2022 | Atlético Junior | - | Envigado FC | 4:0 | ||||
| 19. Round | 08/05/2022 | Cortuluá | - | Atlético Junior | 1:0 | ||||
| 20. Round | 15/05/2022 | Atlético Junior | - | Jaguares de Córdoba | 2:4 |
Venezuela