| 1. Round | 08/07/2022 | Patriotas FC | - | Atlético Junior | 1:0 | ||||
| 2. Round | 14/07/2022 | Atlético Junior | - | Atlético Nacional | 3:1 |  |
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| 3. Round | 17/07/2022 | La Equidad | - | Atlético Junior | 0:0 |  |
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| 4. Round | 24/07/2022 | Atlético Junior | - | Santa Fe | 2:0 | ||||
| 8. Round | 21/08/2022 | América de Cali | - | Atlético Junior | 2:1 | |
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| 9. Round | 29/08/2022 | Atlético Junior | - | Deportes Tolima | 2:1 | ||||
| 10. Round | 04/09/2022 | Unión Magdalena | - | Atlético Junior | 2:1 | ||||
| 11. Round | 10/09/2022 | Atlético Junior | - | Deportivo Pereira | 0:0 | ||||
| 12. Round | 18/09/2022 | Deportivo Pasto | - | Atlético Junior | 2:1 | |
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| 13. Round | 22/09/2022 | Atlético Junior | - | Millonarios | 0:1 | ||||
| 15. Round | 02/10/2022 | Atlético Junior | - | Deportivo Cali | 1:0 | ||||
| 16. Round | 10/10/2022 | Atlético Bucaramanga | - | Atlético Junior | 0:1 | |
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| 17. Round | 14/10/2022 | Atlético Junior | - | Unión Magdalena | 1:1 | ||||
| 18. Round | 17/10/2022 | Envigado FC | - | Atlético Junior | 2:0 | ||||
| 19. Round | 24/10/2022 | Atlético Junior | - | Cortuluá | 2:1 | |
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| 20. Round | 30/10/2022 | Jaguares de Córdoba | - | Atlético Junior | 0:2 |
Venezuela