| 10. Round | 10/10/2021 | Sporting San Miguelito | - | San Francisco FC | 1:1 |  |
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| 11. Round | 16/10/2021 | San Francisco FC | - | Árabe Unido | 1:0 |  |
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| 12. Round | 23/10/2021 | San Francisco FC | - | Atlético Chiriquí | 1:0 | ||||
| 13. Round | 30/10/2021 | UD Universitario | - | San Francisco FC | 0:1 | ||||
| 14. Round | 06/11/2021 | San Francisco FC | - | Independiente de La Chorrera | 1:1 |
Panama