| 1. Round | 18/07/2021 | Sport Huancayo | - | FBC Melgar | 0:3 |  |
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| 2. Round | 25/07/2021 | FBC Melgar | - | Universidad Cesar Vallejo | 1:1 | ||||
| 3. Round | 01/08/2021 | Deportivo Binacional | - | FBC Melgar | 1:5 | ||||
| 4. Round | 04/08/2021 | FBC Melgar | - | Cusco FC | 2:2 | |
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| 5. Round | 09/08/2021 | FBC Melgar | - | Alianza Universidad | 3:0 | ||||
| 6. Round | 13/08/2021 | Alianza Atlético | - | FBC Melgar | 3:3 | |
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| 7. Round | 17/08/2021 | FBC Melgar | - | Universidad Técnica | 0:1 |  |
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| 8. Round | 21/08/2021 | Mannucci | - | FBC Melgar | 1:2 | |
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| 9. Round | 27/08/2021 | FBC Melgar | - | Sporting Cristal | 0:1 | ||||
| 10. Round | 13/09/2021 | Cienciano | - | FBC Melgar | 0:1 | |
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| 11. Round | 18/09/2021 | FBC Melgar | - | Ayacucho FC | 1:1 | ||||
| 12. Round | 22/09/2021 | Alianza Lima | - | FBC Melgar | 1:0 | |
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| 13. Round | 26/09/2021 | FBC Melgar | - | Sport Boys | 1:0 | ||||
| 14. Round | 03/10/2021 | Academia Cantolao | - | FBC Melgar | 0:2 | |
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| 15. Round | 17/10/2021 | FBC Melgar | - | Universidad San Martín | 6:0 | |
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| 16. Round | 24/10/2021 | Deportivo Municipal | - | FBC Melgar | 1:3 | ||||
| 17. Round | 31/10/2021 | FBC Melgar | - | Universitario de Deportes | 1:2 | |
Peru