| 1. Round | 19/07/2001 | Deportivo Toluca | - | Club León | 3:1 |  |
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| 3. Round | 02/08/2001 | Atletico Celaya | - | Club León | 2:1 | ||||
| 4. Round | 10/08/2001 | Club León | - | Deportivo Guadalajara | 1:2 | ||||
| 7. Round | 23/08/2001 | Atlante | - | Club León | 3:1 | ||||
| 8. Round | 07/09/2001 | Club León | - | Monarcas Morelia | 1:1 | ||||
| 9. Round | 13/09/2001 | CF América | - | Club León | 1:2 | ||||
| 10. Round | 21/09/2001 | Club León | - | CF Pachuca | 1:1 | ||||
| 11. Round | 27/09/2001 | UANL Tigres | - | Club León | 1:0 | ||||
| 12. Round | 05/10/2001 | Club León | - | Club Irapuato | 2:2 | ||||
| 13. Round | 11/10/2001 | Atlas Guadalajara | - | Club León | 4:1 | ||||
| 15. Round | 26/10/2001 | Reboceros de la Piedad | - | Club León | 1:1 | ||||
| 16. Round | 02/11/2001 | Club León | - | Cruz Azul | 2:2 | ||||
| 17. Round | 09/11/2001 | Pumas UNAM | - | Club León | 1:1 | ||||
| 18. Round | 16/11/2001 | Puebla FC | - | Club León | 2:2 |  |
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| 19. Round | 23/11/2001 | Club León | - | Club Necaxa | 2:1 | |
Argentina