| 1. Round | 09/02/2022 | Boca Juniors de Cali | - | Fortaleza FC | 0:1 | ||||
| 2. Round | 02/03/2022 | Valledupar FC | - | Fortaleza FC | 0:2 |  |
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| 3. Round | 30/03/2022 | Cortuluá | - | Fortaleza FC | 0:1 | ||||
| 3. Round | 07/04/2022 | Fortaleza FC | - | Cortuluá | 1:0 | |
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| Round of 16 | 21/04/2022 | Deportivo Cali | - | Fortaleza FC | 1:3 | ||||
| Round of 16 | 13/05/2022 | Fortaleza FC | - | Deportivo Cali | 1:1 | ||||
| Quarter-finals | 28/07/2022 | Millonarios | - | Fortaleza FC | 3:0 | ||||
| Quarter-finals | 18/08/2022 | Fortaleza FC | - | Millonarios | 2:3 |
Colombia