| 1. Round | 26/07/2021 | Unión Magdalena | - | Fortaleza FC | 3:1 | ||||
| 2. Round | 02/08/2021 | Fortaleza FC | - | Boca Juniors de Cali | 3:0 | ||||
| 3. Round | 06/08/2021 | Real Cartagena | - | Fortaleza FC | 0:1 | ||||
| 4. Round | 14/08/2021 | Fortaleza FC | - | Leones FC | 3:1 |  |
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| 5. Round | 22/08/2021 | Llaneros FC | - | Fortaleza FC | 1:1 | ||||
| 6. Round | 28/08/2021 | Fortaleza FC | - | Tigres FC | 2:1 | ||||
| 7. Round | 04/09/2021 | Barranquilla FC | - | Fortaleza FC | 0:0 | ||||
| 8. Round | 15/09/2021 | Fortaleza FC | - | Bogotá FC | 3:0 | ||||
| 9. Round | 19/09/2021 | Atlético FC | - | Fortaleza FC | 0:3 | ||||
| 10. Round | 25/09/2021 | Fortaleza FC | - | Orsomarso SC | 4:0 | ||||
| 11. Round | 03/10/2021 | Valledupar FC | - | Fortaleza FC | 1:1 | ||||
| 12. Round | 13/10/2021 | Fortaleza FC | - | Boyacá Chicó | 0:0 |  |
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| 14. Round | 24/10/2021 | Real Santander | - | Fortaleza FC | 1:1 | ||||
| 15. Round | 30/10/2021 | Fortaleza FC | - | Cortuluá | 1:2 |
Colombia