| 9. Round | 01/03/2021 | Real Estelí FC | - | Managua FC | 1:1 | ||||
| 10. Round | 07/03/2021 | Real Estelí FC | - | Club Deportivo Ocotal | 1:1 | ||||
| 14. Round | 20/04/2021 | Real Estelí FC | - | ART Municipal Jalapa | 1:0 | ||||
| 13. Round | 23/04/2021 | Real Estelí FC | - | Juventus Managua | 4:0 |  |
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| 15. Round | 26/04/2021 | Real Estelí FC | - | CD Walter Ferretti | 2:1 | ||||
| 17. Round | 02/05/2021 | Junior Managua | - | Real Estelí FC | 0:2 |  |
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| 18. Round | 07/05/2021 | Managua FC | - | Real Estelí FC | 1:0 |
Nicaragua