2. Round | 12/08/2021 | Olimpia | - | Real España | 1:1 | ||||
3. Round | 15/08/2021 | Platense | - | Real España | 0:2 | ||||
4. Round | 22/08/2021 | Real España | - | Real Sociedad | 1:1 | ||||
5. Round | 26/08/2021 | Real España | - | Lobos UPNFM | 5:3 | ||||
8. Round | 12/09/2021 | Real España | - | Motagua | 2:1 | ||||
10. Round | 20/09/2021 | Real España | - | Marathón | 0:1 | ||||
11. Round | 26/09/2021 | Real Sociedad | - | Real España | 0:4 | ||||
12. Round | 02/10/2021 | Real España | - | Olimpia | 1:1 | ||||
1. Round | 21/10/2021 | Real España | - | Victoria | 1:1 | ||||
15. Round | 24/10/2021 | Lobos UPNFM | - | Real España | 1:2 | ||||
16. Round | 28/10/2021 | Real España | - | Honduras Progreso | 4:1 | ||||
17. Round | 30/10/2021 | Motagua | - | Real España | 0:1 |