| 1. Round | 16/01/2022 | Luis Ángel Firpo | - | Municipal Limeño | 1:0 | ||||
| 12. Round | 13/03/2022 | Municipal Limeño | - | Luis Ángel Firpo | 3:2 |  |
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| 13. Round | 20/03/2022 | Platense Zacatecoluca | - | Municipal Limeño | 1:0 | |
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| 14. Round | 25/03/2022 | Municipal Limeño | - | Once Municipal | 0:0 | ||||
| 15. Round | 03/04/2022 | CD Águila | - | Municipal Limeño | 1:0 | ||||
| 16. Round | 10/04/2022 | Municipal Limeño | - | Jocoro FC | 2:2 | ||||
| 17. Round | 13/04/2022 | FAS | - | Municipal Limeño | 1:1 | ||||
| 18. Round | 17/04/2022 | Municipal Limeño | - | Santa Tecla FC | 2:0 | ||||
| 19. Round | 24/04/2022 | Alianza | - | Municipal Limeño | 4:0 | ||||
| 20. Round | 27/04/2022 | Atlético Marte | - | Municipal Limeño | 0:1 | |
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| 21. Round | 01/05/2022 | Municipal Limeño | - | Isidro Metapán | 1:0 | ||||
| 22. Round | 07/05/2022 | AD Chalatenango | - | Municipal Limeño | 0:0 |
El Salvador