| 1. Round | 25/01/2022 | Deportes Quindío | - | Bogotá FC | 1:2 | ||||
| 2. Round | 31/01/2022 | Orsomarso SC | - | Deportes Quindío | 1:1 | ||||
| 3. Round | 06/02/2022 | Deportes Quindío | - | Llaneros FC | 0:0 | ||||
| 5. Round | 21/02/2022 | Boyacá Chicó | - | Deportes Quindío | 2:3 | ||||
| 6. Round | 28/02/2022 | Deportes Quindío | - | Boca Juniors de Cali | 1:0 |  |
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| 7. Round | 07/03/2022 | Valledupar FC | - | Deportes Quindío | 0:0 | ||||
| 8. Round | 10/03/2022 | Deportes Quindío | - | Tigres FC | 0:0 | ||||
| 9. Round | 20/03/2022 | Fortaleza FC | - | Deportes Quindío | 2:2 | ||||
| 10. Round | 26/03/2022 | Deportes Quindío | - | Barranquilla FC | 2:1 | ||||
| 11. Round | 03/04/2022 | Atlético Huila | - | Deportes Quindío | 0:0 | ||||
| 12. Round | 12/04/2022 | Deportes Quindío | - | Real Cartagena | 5:0 | |
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| 13. Round | 16/04/2022 | Real Santander | - | Deportes Quindío | 0:1 | ||||
| 14. Round | 23/04/2022 | Deportes Quindío | - | Atlético FC | 1:0 | |
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Colombia