| 1. Round | 18/01/2021 | Deportes Tolima | - | Once Caldas | 1:1 | ||||
| 3. Round | 31/01/2021 | Deportes Tolima | - | La Equidad | 1:0 | ||||
| 4. Round | 03/02/2021 | Deportivo Pereira | - | Deportes Tolima | 0:0 |  |
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| 5. Round | 07/02/2021 | Deportes Tolima | - | Independiente Medellín | 2:1 | |
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| 10. Round | 28/02/2021 | Deportes Tolima | - | Águilas Doradas | 1:0 | |
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| 2. Round | 05/03/2021 | Santa Fe | - | Deportes Tolima | 3:2 | |
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| 11. Round | 08/03/2021 | Boyacá Chicó | - | Deportes Tolima | 2:1 | ||||
| 12. Round | 13/03/2021 | Deportes Tolima | - | Jaguares de Córdoba | 3:2 | ||||
| 13. Round | 21/03/2021 | Deportivo Cali | - | Deportes Tolima | 0:0 | ||||
| 14. Round | 24/03/2021 | Deportes Tolima | - | Atlético Junior | 0:1 | ||||
| 15. Round | 27/03/2021 | Envigado FC | - | Deportes Tolima | 0:0 | ||||
| 16. Round | 31/03/2021 | Deportes Tolima | - | Atlético Nacional | 2:1 |
Colombia