| 1. Round | 16/01/2021 | Orsomarso SC | - | Barranquilla FC | 2:2 |  |
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| 3. Round | 30/01/2021 | Orsomarso SC | - | Llaneros FC | 0:0 | ||||
| 4. Round | 06/02/2021 | Unión Magdalena | - | Orsomarso SC | 1:1 | ||||
| 6. Round | 15/02/2021 | Tigres FC | - | Orsomarso SC | 2:0 | ||||
| 8. Round | 27/02/2021 | Orsomarso SC | - | Real Cartagena | 3:3 | ||||
| 9. Round | 03/03/2021 | Real Santander | - | Orsomarso SC | 1:2 | ||||
| 10. Round | 07/03/2021 | Orsomarso SC | - | Bogotá FC | 4:2 | ||||
| 12. Round | 22/03/2021 | Orsomarso SC | - | Leones FC | 1:1 | ||||
| 14. Round | 03/04/2021 | Orsomarso SC | - | Cortuluá | 1:2 | |
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| 15. Round | 09/04/2021 | Atlético FC | - | Orsomarso SC | 0:0 |
Colombia