| 1. Round | 26/07/2018 | Atlético Nacional | - | Deportes Tolima | 1:2 | ||||
| 5. Round | 19/08/2018 | Atlético Bucaramanga | - | Deportes Tolima | 0:2 | ||||
| 7. Round | 02/09/2018 | Envigado FC | - | Deportes Tolima | 1:3 | ||||
| 9. Round | 08/09/2018 | Boyacá Chicó | - | Deportes Tolima | 2:1 |  |
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| 10. Round | 16/09/2018 | Deportes Tolima | - | Independiente Medellín | 3:0 | ||||
| 11. Round | 23/09/2018 | Deportivo Cali | - | Deportes Tolima | 0:1 | ||||
| 15. Round | 18/10/2018 | La Equidad | - | Deportes Tolima | 0:1 | |
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| 16. Round | 21/10/2018 | Deportes Tolima | - | Leones FC | 3:2 | ||||
| 17. Round | 28/10/2018 | Millonarios | - | Deportes Tolima | 1:1 | ||||
| 18. Round | 03/11/2018 | Santa Fe | - | Deportes Tolima | 3:0 | |
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| 19. Round | 10/11/2018 | Deportes Tolima | - | Patriotas FC | 2:1 |
Colombia