| 15. Round | 23/10/2021 | Achuapa | - | Cobán Imperial | 1:0 | ||||
| 17. Round | 31/10/2021 | Cobán Imperial | - | Deportivo Malacateco | 1:1 | ||||
| 18. Round | 07/11/2021 | Antigua GFC | - | Cobán Imperial | 2:1 |  |
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| 19. Round | 13/11/2021 | Cobán Imperial | - | Deportivo Guastatoya | 0:1 | ||||
| 20. Round | 20/11/2021 | Santa Lucía | - | Cobán Imperial | 2:2 |
Guatemala