| 1. Round | 06/02/2022 | San Francisco FC | - | Veraguas United | 0:1 | ||||
| 2. Round | 13/02/2022 | Herrera FC | - | Veraguas United | 2:0 | ||||
| 5. Round | 06/03/2022 | Veraguas United | - | Atlético Chiriquí | 1:3 | ||||
| 6. Round | 10/03/2022 | Alianza | - | Veraguas United | 2:0 | ||||
| 7. Round | 13/03/2022 | Veraguas United | - | Plaza Amador | 1:1 | ||||
| 8. Round | 19/03/2022 | Veraguas United | - | Sporting San Miguelito | 1:2 | ||||
| 9. Round | 26/03/2022 | Veraguas United | - | Potros del Este | 1:1 |  |
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| 10. Round | 03/04/2022 | Árabe Unido | - | Veraguas United | 0:0 | ||||
| 11. Round | 09/04/2022 | Tauro FC | - | Veraguas United | 4:1 | ||||
| 13. Round | 23/04/2022 | Veraguas United | - | Herrera FC | 2:2 | ||||
| 14. Round | 28/04/2022 | Veraguas United | - | UD Universitario | 1:0 |
Panama