| 2. Round | 13/02/2022 | Herrera FC | - | Veraguas United | 2:0 | ||||
| 5. Round | 05/03/2022 | Herrera FC | - | San Francisco FC | 0:0 | ||||
| 8. Round | 20/03/2022 | Herrera FC | - | Alianza | 0:0 | ||||
| 10. Round | 02/04/2022 | Herrera FC | - | Potros del Este | 1:2 | ||||
| 15. Round | 02/05/2022 | Atlético Chiriquí | - | Herrera FC | 0:0 | ||||
| 16. Round | 08/05/2022 | San Francisco FC | - | Herrera FC | 3:1 |
Panama