| 2. Round | 28/02/2021 | Atlético Chiriquí | - | Herrera FC | 0:2 | ||||
| 3. Round | 05/03/2021 | Herrera FC | - | Veraguas Club Deportivo | 1:2 |  |
|||
| 4. Round | 14/03/2021 | Herrera FC | - | San Francisco FC | 1:0 | ||||
| 5. Round | 17/03/2021 | UD Universitario | - | Herrera FC | 4:0 | ||||
| 6. Round | 21/03/2021 | Herrera FC | - | Árabe Unido | 0:0 | ||||
| 8. Round | 28/03/2021 | Herrera FC | - | Tauro FC | 1:1 | ||||
| 9. Round | 05/04/2021 | Herrera FC | - | Sporting San Miguelito | 2:0 | |
|||
| 10. Round | 11/04/2021 | Plaza Amador | - | Herrera FC | 3:1 | |
 |
||
| 11. Round | 18/04/2021 | Alianza | - | Herrera FC | 2:3 | ||||
| 12. Round | 22/04/2021 | Independiente de La Chorrera | - | Herrera FC | 1:3 | ||||
| 13. Round | 25/04/2021 | Herrera FC | - | Atlético Chiriquí | 3:0 | |
|||
| 14. Round | 29/04/2021 | Veraguas Club Deportivo | - | Herrera FC | 0:0 | ||||
| 15. Round | 03/05/2021 | San Francisco FC | - | Herrera FC | 0:0 | ||||
| 16. Round | 08/05/2021 | Herrera FC | - | UD Universitario | 2:0 |
Panama