| 1. Round | 08/08/2021 | Independiente de La Chorrera | - | Herrera FC | 1:3 | ||||
| 2. Round | 15/08/2021 | Herrera FC | - | Atlético Chiriquí | 0:0 | ||||
| 3. Round | 22/08/2021 | Veraguas Club Deportivo | - | Herrera FC | 1:1 | ||||
| 4. Round | 28/08/2021 | San Francisco FC | - | Herrera FC | 1:3 | ||||
| 5. Round | 04/09/2021 | Herrera FC | - | UD Universitario | 1:2 |  |
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| 6. Round | 11/09/2021 | Árabe Unido | - | Herrera FC | 1:1 | |
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| 7. Round | 18/09/2021 | Herrera FC | - | Deportivo del Este | 1:1 | |
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| 8. Round | 26/09/2021 | Tauro FC | - | Herrera FC | 1:1 | ||||
| 9. Round | 03/10/2021 | Sporting San Miguelito | - | Herrera FC | 1:1 | |
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| 10. Round | 10/10/2021 | Herrera FC | - | Plaza Amador | 0:2 | ||||
| 13. Round | 31/10/2021 | Atlético Chiriquí | - | Herrera FC | 0:0 | ||||
| 14. Round | 06/11/2021 | Herrera FC | - | Veraguas Club Deportivo | 1:1 | ||||
| 15. Round | 13/11/2021 | Herrera FC | - | San Francisco FC | 2:1 | ||||
| 16. Round | 20/11/2021 | UD Universitario | - | Herrera FC | 1:2 |
Panama