| 1. Round | 06/02/2022 | San Francisco FC | - | Veraguas United | 0:1 | ||||
| 7. Round | 13/03/2022 | Alianza | - | San Francisco FC | 2:1 | ||||
| 8. Round | 20/03/2022 | Tauro FC | - | San Francisco FC | 1:0 |  |
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| 9. Round | 26/03/2022 | San Francisco FC | - | Sporting San Miguelito | 0:1 | ||||
| 10. Round | 02/04/2022 | San Francisco FC | - | Plaza Amador | 2:2 |  |
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| 11. Round | 09/04/2022 | Potros del Este | - | San Francisco FC | 0:0 |
Panama