1. Round | 08/08/2021 | Honduras Progreso | - | Marathón | 1:2 | ||||
3. Round | 14/08/2021 | Marathón | - | Motagua | 2:0 | ||||
4. Round | 22/08/2021 | Vida | - | Marathón | 2:0 | ||||
6. Round | 29/08/2021 | Marathón | - | Real España | 0:1 | ||||
7. Round | 04/09/2021 | Marathón | - | Real Sociedad | 2:1 | ||||
8. Round | 12/09/2021 | Victoria | - | Marathón | 1:0 | ||||
9. Round | 15/09/2021 | Marathón | - | Olimpia | 3:1 | ||||
10. Round | 20/09/2021 | Real España | - | Marathón | 0:1 | ||||
11. Round | 25/09/2021 | Marathón | - | Vida | 1:2 | ||||
15. Round | 24/10/2021 | Marathón | - | Platense | 1:1 | ||||
16. Round | 28/10/2021 | Olimpia | - | Marathón | 1:0 | ||||
17. Round | 30/10/2021 | Marathón | - | Victoria | 0:0 |