| 1. Round | 31/07/2022 | Real Sociedad | - | Marathón | 0:2 | ||||
| 2. Round | 07/08/2022 | Honduras Progreso | - | Marathón | 0:2 | ||||
| 5. Round | 20/08/2022 | Marathón | - | Vida | 4:4 | ||||
| 7. Round | 01/09/2022 | Marathón | - | Victoria | 1:1 | ||||
| 8. Round | 04/09/2022 | Marathón | - | Lobos UPNFM | 1:1 | ||||
| 9. Round | 11/09/2022 | Olancho FC | - | Marathón | 2:3 | ||||
| 10. Round | 18/09/2022 | Marathón | - | Real Sociedad | 3:0 |  |
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| 11. Round | 01/10/2022 | Marathón | - | Honduras Progreso | 5:1 | ||||
| 12. Round | 09/10/2022 | Olimpia | - | Marathón | 1:0 | ||||
| 14. Round | 20/10/2022 | Vida | - | Marathón | 2:2 | ||||
| 15. Round | 23/10/2022 | Marathón | - | Real España | 2:0 | |
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| 17. Round | 13/11/2022 | Lobos UPNFM | - | Marathón | 2:1 | ||||
| 18. Round | 19/11/2022 | Marathón | - | Olancho FC | 4:0 |  |
Honduras