| 2. Round | 21/08/2021 | NK Rudeš | - | HNK Orijent Rijeka | 2:2 | ||||
| 3. Round | 27/08/2021 | HNK Cibalia | - | NK Rudeš | 2:1 | ||||
| 4. Round | 11/09/2021 | NK Rudeš | - | NK Inter Zaprešić | 3:0 | ||||
| 5. Round | 15/09/2021 | NK Kustošija | - | NK Rudeš | 1:2 |  |
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| 10. Round | 23/10/2021 | NK Rudeš | - | NK Opatija | 3:0 | |
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| 13. Round | 20/11/2021 | NK Rudeš | - | NK Jarun | 3:0 | |
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| 14. Round | 26/11/2021 | NK Sesvete | - | NK Rudeš | 0:0 | ||||
| 15. Round | 04/12/2021 | NK Rudeš | - | NK Dugopolje | 4:0 | |
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| 16. Round | 12/02/2022 | NK Rudeš | - | NK Dubrava | 4:1 |  |
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| 19. Round | 04/03/2022 | NK Inter Zaprešić | - | NK Rudeš | 1:0 | ||||
| 20. Round | 12/03/2022 | NK Rudeš | - | NK Kustošija | 2:0 | ||||
| 18. Round | 16/03/2022 | NK Rudeš | - | HNK Cibalia | 4:0 | ||||
| 21. Round | 20/03/2022 | NK BSK Bijelo Brdo | - | NK Rudeš | 2:1 | ||||
| 22. Round | 02/04/2022 | NK Rudeš | - | Dinamo Zagreb II | 3:2 | ||||
| 23. Round | 09/04/2022 | NK Solin | - | NK Rudeš | 1:2 | ||||
| 24. Round | 16/04/2022 | NK Rudeš | - | NK Croatia Zmijavci | 2:0 | ||||
| 25. Round | 23/04/2022 | NK Opatija | - | NK Rudeš | 3:1 | ||||
| 26. Round | 30/04/2022 | NK Rudeš | - | NK Varaždin | 3:0 | ||||
| 27. Round | 07/05/2022 | NK Rudeš | - | NK Osijek II | 1:0 | ||||
| 29. Round | 21/05/2022 | NK Rudeš | - | NK Sesvete | 3:0 |
Croatia