| 1. Round | 12/04/2022 | Longford Town | - | Cobh Ramblers | 2:0 | ||||
| 15. Round | 06/05/2022 | Cobh Ramblers | - | Galway United | 0:4 | ||||
| 16. Round | 13/05/2022 | Waterford FC | - | Cobh Ramblers | 4:2 |  |
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| 17. Round | 20/05/2022 | Treaty United | - | Cobh Ramblers | 2:2 | ||||
| 18. Round | 27/05/2022 | Cobh Ramblers | - | Longford Town | 2:4 | ||||
| 19. Round | 10/06/2022 | Athlone Town | - | Cobh Ramblers | 5:2 | ||||
| 20. Round | 17/06/2022 | Cobh Ramblers | - | Wexford FC | 0:3 | ||||
| 21. Round | 24/06/2022 | Cork City | - | Cobh Ramblers | 1:0 | ||||
| 23. Round | 01/07/2022 | Cobh Ramblers | - | Treaty United | 0:2 | ||||
| 29. Round | 19/08/2022 | Cobh Ramblers | - | Cork City | 1:2 | ||||
| 30. Round | 02/09/2022 | Treaty United | - | Cobh Ramblers | 1:0 | ||||
| 31. Round | 09/09/2022 | Cobh Ramblers | - | Galway United | 1:1 | |
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| 32. Round | 16/09/2022 | Cobh Ramblers | - | Athlone Town | 1:3 | |
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| 33. Round | 30/09/2022 | Waterford FC | - | Cobh Ramblers | 3:1 | ||||
| 34. Round | 07/10/2022 | Cobh Ramblers | - | Longford Town | 2:4 | ||||
| 35. Round | 14/10/2022 | Bray Wanderers | - | Cobh Ramblers | 1:5 |  |
Ireland