| 1. Round | 08/08/2022 | Nottingham Forest U21 | - | Southampton FC U21 | 1:3 | ||||
| 2. Round | 12/08/2022 | Southampton FC U21 | - | West Bromwich Albion U21 | 4:1 | ||||
| 3. Round | 19/08/2022 | Stoke City U21 | - | Southampton FC U21 | 0:3 |  |
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| 4. Round | 26/08/2022 | Southampton FC U21 | - | Norwich City U21 | 1:1 | ||||
| 6. Round | 16/09/2022 | Leeds United U21 | - | Southampton FC U21 | 6:2 | ||||
| 8. Round | 08/10/2022 | Southampton FC U21 | - | Aston Villa U21 | 2:0 | |
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| 9. Round | 23/10/2022 | Newcastle United U21 | - | Southampton FC U21 | 3:2 | ||||
| 11. Round | 07/11/2022 | Sunderland AFC U21 | - | Southampton FC U21 | 1:3 | ||||
| 12. Round | 06/01/2023 | Southampton FC U21 | - | Derby County U21 | 3:0 | ||||
| 13. Round | 13/01/2023 | Southampton FC U21 | - | Newcastle United U21 | 4:1 |  |
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| 14. Round | 27/01/2023 | Middlesbrough FC U21 | - | Southampton FC U21 | 2:2 |
England