10. Round | 30/10/2021 | Watford FC | - | Southampton FC | 0:1 | ||||
11. Round | 05/11/2021 | Southampton FC | - | Aston Villa | 1:0 | ||||
12. Round | 20/11/2021 | Norwich City | - | Southampton FC | 2:1 | ||||
13. Round | 27/11/2021 | Liverpool FC | - | Southampton FC | 4:0 | ||||
14. Round | 01/12/2021 | Southampton FC | - | Leicester City | 2:2 | ||||
15. Round | 04/12/2021 | Southampton FC | - | Brighton & Hove Albion | 1:1 | ||||
16. Round | 11/12/2021 | Arsenal FC | - | Southampton FC | 3:0 | ||||
17. Round | 15/12/2021 | Crystal Palace | - | Southampton FC | 2:2 | ||||
18. Round | 11/01/2022 | Southampton FC | - | Brentford FC | 4:1 | ||||
22. Round | 15/01/2022 | Wolverhampton Wanderers | - | Southampton FC | 3:1 | ||||
23. Round | 22/01/2022 | Southampton FC | - | Manchester City | 1:1 | ||||
33. Round | 16/04/2022 | Southampton FC | - | Arsenal FC | 1:0 | ||||
30. Round | 21/04/2022 | Burnley FC | - | Southampton FC | 2:0 | ||||
37. Round | 17/05/2022 | Southampton FC | - | Liverpool FC | 1:2 | ||||
38. Round | 22/05/2022 | Leicester City | - | Southampton FC | 4:1 |