| 16. Round | 22/04/2021 | El Entag El Harby | - | Zamalek | 0:2 | ||||
| 17. Round | 26/04/2021 | Zamalek | - | National Bank SC | 4:1 | ||||
| 20. Round | 06/05/2021 | Zamalek | - | Smouha Sporting Club | 2:1 | ||||
| 24. Round | 24/05/2021 | Zamalek | - | Al Masry Club | 3:2 |  |
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| 26. Round | 17/06/2021 | Zamalek | - | Aswan SC | 3:0 | ||||
| 28. Round | 07/08/2021 | Zamalek | - | Ghazl Al Mehalla | 3:0 | ||||
| 29. Round | 10/08/2021 | Ittihad El Iskandary | - | Zamalek | 1:2 | ||||
| 30. Round | 14/08/2021 | Ismaily | - | Zamalek | 0:2 | ||||
| 34. Round | 27/08/2021 | National Bank SC | - | Zamalek | 1:1 |
Egypt