| 13. Round | 16/03/2022 | El Gouna | - | Al Mokawloon | 1:2 | ||||
| 17. Round | 01/05/2022 | Al Masry Club | - | Al Mokawloon | 0:2 | ||||
| 19. Round | 15/05/2022 | Al Mokawloon | - | ENPPI | 2:2 |  |
 |
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| 20. Round | 21/05/2022 | Tala'ea El Gaish SC | - | Al Mokawloon | 1:0 | ||||
| 22. Round | 17/06/2022 | Ismaily | - | Al Mokawloon | 0:0 | ||||
| 23. Round | 28/06/2022 | Al Mokawloon | - | National Bank SC | 1:1 | ||||
| 24. Round | 12/07/2022 | Zamalek | - | Al Mokawloon | 1:0 | ||||
| 25. Round | 17/07/2022 | Al Mokawloon | - | Ceramica Cleopatra | 0:1 | ||||
| 26. Round | 22/07/2022 | Al Mokawloon | - | Ghazl Al Mehalla | 1:0 | ||||
| 27. Round | 27/07/2022 | Smouha Sporting Club | - | Al Mokawloon | 1:1 | ||||
| 21. Round | 30/07/2022 | Al Mokawloon | - | Al Ahly SC | 0:0 | ||||
| 28. Round | 02/08/2022 | Al Mokawloon | - | Future FC | 0:1 | ||||
| 29. Round | 06/08/2022 | Pyramids FC | - | Al Mokawloon | 1:0 | ||||
| 31. Round | 19/08/2022 | Misr lel-Maqasah SC | - | Al Mokawloon | 0:3 | ||||
| 32. Round | 23/08/2022 | Al Mokawloon | - | Pharco FC | 2:0 |  |
Egypt