| 14. Round | 01/03/2021 | Wadi Degla SC | - | Zamalek | 0:0 | ||||
| 15. Round | 11/03/2021 | Zamalek | - | Ceramica Cleopatra | 2:0 | ||||
| 4. Round | 18/04/2021 | Zamalek | - | Al Ahly SC | 1:2 | ||||
| 18. Round | 29/04/2021 | Zamalek | - | Al Mokawloon | 2:2 | ||||
| 26. Round | 17/06/2021 | Zamalek | - | Aswan SC | 3:0 | ||||
| 27. Round | 28/06/2021 | Misr lel-Maqasah SC | - | Zamalek | 0:1 | ||||
| 28. Round | 07/08/2021 | Zamalek | - | Ghazl Al Mehalla | 3:0 | ||||
| 29. Round | 10/08/2021 | Ittihad El Iskandary | - | Zamalek | 1:2 | ||||
| 30. Round | 14/08/2021 | Ismaily | - | Zamalek | 0:2 |
Egypt