| 8. Round | 07/05/2021 | FK Smorgon | - | Neman Grodno | 0:2 | ||||
| 10. Round | 22/05/2021 | Rukh Brest | - | Neman Grodno | 2:0 | ||||
| 13. Round | 17/06/2021 | Neman Grodno | - | FK Slaviya Mozyr | 2:2 | ||||
| 15. Round | 03/07/2021 | Torpedo-BelAZ Zhodino | - | Neman Grodno | 1:1 | ||||
| 18. Round | 02/08/2021 | Dinamo Brest | - | Neman Grodno | 1:3 | ||||
| 19. Round | 15/08/2021 | Neman Grodno | - | FK Gomel | 1:0 | ||||
| 20. Round | 22/08/2021 | FK Minsk | - | Neman Grodno | 0:4 | ||||
| 21. Round | 29/08/2021 | Neman Grodno | - | Energetik-BGU Minsk | 3:0 | ||||
| 27. Round | 22/10/2021 | Neman Grodno | - | BATE Borisov | 0:2 | ||||
| 30. Round | 28/11/2021 | Neman Grodno | - | Torpedo-BelAZ Zhodino | 3:1 |
Belarus