| 2. Round | 16/04/2010 | Toronto FC | - | Philadelphia Union | 2:1 |  |
|||
| 2. Round | 18/04/2010 | Colorado Rapids | - | Toronto FC | 3:1 | |
|||
| 2. Round | 25/04/2010 | Toronto FC | - | Seattle Sounders | 2:0 | |
|||
| 3. Round | 02/05/2010 | Real Salt Lake | - | Toronto FC | 2:1 | ||||
| 3. Round | 08/05/2010 | Toronto FC | - | Chicago Fire | 4:1 | ||||
| 3. Round | 16/05/2010 | Los Angeles Galaxy | - | Toronto FC | 0:0 |  |
|||
| 5. Round | 10/07/2010 | Toronto FC | - | Colorado Rapids | 1:0 | ||||
| 5. Round | 17/07/2010 | Philadelphia Union | - | Toronto FC | 2:1 | ||||
| 6. Round | 12/08/2010 | New York RB | - | Toronto FC | 1:0 | ||||
| 6. Round | 29/08/2010 | Toronto FC | - | Real Salt Lake | 0:0 | ||||
| 7. Round | 05/09/2010 | FC Dallas | - | Toronto FC | 1:0 | ||||
| 7. Round | 09/09/2010 | Chicago Fire | - | Toronto FC | 0:0 | |
|||
| 7. Round | 19/09/2010 | Houston Dynamo | - | Toronto FC | 1:2 | ||||
| 8. Round | 10/10/2010 | CD Chivas | - | Toronto FC | 3:0 |
Russia