| 1. Round | 24/10/2020 | San Francisco FC | - | Atlético Chiriquí | 1:1 | ||||
| 2. Round | 30/10/2020 | Plaza Amador | - | San Francisco FC | 0:0 | ||||
| 3. Round | 09/11/2020 | San Francisco FC | - | Alianza | 0:0 | ||||
| 4. Round | 14/11/2020 | UD Universitario | - | San Francisco FC | 0:1 |  |
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| 5. Round | 18/11/2020 | Sporting San Miguelito | - | San Francisco FC | 1:2 | ||||
| 8. Round | 28/11/2020 | San Francisco FC | - | Árabe Unido | 3:0 | ||||
| 6. Round | 02/12/2020 | San Francisco FC | - | Independiente de La Chorrera | 1:1 | |
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| 9. Round | 07/12/2020 | San Francisco FC | - | Costa del Este FC | 0:0 |
Panama