| 16. Round | 20/02/2022 | UE Sant Julià | - | UE Santa Coloma | 0:4 | ||||
| 17. Round | 27/02/2022 | UE Santa Coloma | - | Inter Club d'Escaldes | 1:0 | ||||
| 18. Round | 06/03/2022 | Atlétic Escaldes | - | UE Santa Coloma | 1:1 | ||||
| 19. Round | 13/03/2022 | FC Ordino | - | UE Santa Coloma | 0:1 | ||||
| 21. Round | 03/04/2022 | CE Carroi | - | UE Santa Coloma | 1:3 |
Spain