| 1. Round | 19/09/2021 | UE Santa Coloma | - | FC Santa Coloma | 2:1 |  |
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| 2. Round | 26/09/2021 | FC Santa Coloma | - | UE Engordany | 1:1 | |
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| 3. Round | 03/10/2021 | CE Carroi | - | FC Santa Coloma | 2:5 | ||||
| 4. Round | 17/10/2021 | FC Santa Coloma | - | FC Ordino | 3:2 | ||||
| 5. Round | 24/10/2021 | FC Santa Coloma | - | UE Sant Julià | 1:3 | ||||
| 6. Round | 31/10/2021 | Inter Club d'Escaldes | - | FC Santa Coloma | 1:1 | ||||
| 7. Round | 07/11/2021 | FC Santa Coloma | - | Atlétic Escaldes | 1:3 |  |
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| 10. Round | 19/12/2021 | FC Santa Coloma | - | CE Carroi | 3:0 | ||||
| 12. Round | 19/01/2022 | UE Sant Julià | - | FC Santa Coloma | 0:0 | ||||
| 11. Round | 02/02/2022 | FC Ordino | - | FC Santa Coloma | 0:0 | ||||
| 19. Round | 13/03/2022 | FC Santa Coloma | - | UE Sant Julià | 2:0 | ||||
| 20. Round | 20/03/2022 | Inter Club d'Escaldes | - | FC Santa Coloma | 1:2 | ||||
| 21. Round | 03/04/2022 | FC Santa Coloma | - | Atlétic Escaldes | 1:1 |
Andorra
Spain