| 1. Round | 31/07/2010 | KV Mechelen | - | Sporting Lokeren | 2:0 | ||||
| 4. Round | 21/08/2010 | Sporting Lokeren | - | RSC Anderlecht | 0:3 | ||||
| 5. Round | 28/08/2010 | Cercle Brugge | - | Sporting Lokeren | 1:1 | ||||
| 6. Round | 12/09/2010 | Sporting Lokeren | - | KVC Westerlo | 3:1 | ||||
| 7. Round | 18/09/2010 | KRC Genk | - | Sporting Lokeren | 3:1 | ||||
| 8. Round | 22/09/2010 | Sporting Lokeren | - | KAA Gent | 3:2 | ||||
| 9. Round | 25/09/2010 | KAS Eupen | - | Sporting Lokeren | 0:1 | ||||
| 10. Round | 02/10/2010 | Sporting Lokeren | - | Germinal Beerschot | 1:0 | ||||
| 13. Round | 30/10/2010 | SV Zulte Waregem | - | Sporting Lokeren | 1:1 | ||||
| 15. Round | 13/11/2010 | Sporting Lokeren | - | Sint-Truidense VV | 3:0 | ||||
| 17. Round | 18/01/2011 | KV Kortrijk | - | Sporting Lokeren | 0:0 | ||||
| 24. Round | 29/01/2011 | Sporting Lokeren | - | KAS Eupen | 0:2 | ||||
| 20. Round | 02/02/2011 | Sporting Lokeren | - | Cercle Brugge | 2:1 | ||||
| 26. Round | 12/02/2011 | Sporting Lokeren | - | Sporting Charleroi | 1:1 | ||||
| 21. Round | 16/02/2011 | KVC Westerlo | - | Sporting Lokeren | 1:2 | ||||
| 28. Round | 05/03/2011 | Sporting Lokeren | - | SV Zulte Waregem | 2:1 |
Congo DR