| 1. Round | 05/02/2022 | Montevideo City Torque | - | Cerro Largo | 1:1 | ||||
| 2. Round | 11/02/2022 | Montevideo City Torque | - | Fénix | 1:2 | ||||
| 3. Round | 19/02/2022 | Defensor Sporting | - | Montevideo City Torque | 1:3 |  |
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| 4. Round | 28/02/2022 | Montevideo City Torque | - | Albion | 1:2 | ||||
| 5. Round | 13/03/2022 | Nacional | - | Montevideo City Torque | 1:1 | ||||
| 6. Round | 22/03/2022 | Montevideo City Torque | - | Danubio | 1:1 | ||||
| 7. Round | 04/04/2022 | Deportivo Maldonado | - | Montevideo City Torque | 2:1 |  |
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| 8. Round | 12/04/2022 | Montevideo City Torque | - | Rentistas | 2:0 | ||||
| 9. Round | 16/04/2022 | Liverpool | - | Montevideo City Torque | 2:0 | |
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| 10. Round | 23/04/2022 | Montevideo City Torque | - | Peñarol | 0:1 | ||||
| 11. Round | 06/05/2022 | Cerrito | - | Montevideo City Torque | 2:2 | |
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| 12. Round | 15/05/2022 | Montevideo Wanderers | - | Montevideo City Torque | 1:1 | |
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| 13. Round | 23/05/2022 | Montevideo City Torque | - | Plaza Colonia | 1:1 | |
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| 14. Round | 28/05/2022 | Boston River | - | Montevideo City Torque | 3:1 | |
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| 15. Round | 03/06/2022 | Montevideo City Torque | - | River Plate | 0:0 |
Chile