| 8. Round | 12/09/2021 | Once Municipal | - | FAS | 1:3 | ||||
| 9. Round | 16/09/2021 | Isidro Metapán | - | Once Municipal | 0:1 | ||||
| 10. Round | 19/09/2021 | Once Municipal | - | Atlético Marte | 0:0 | ||||
| 11. Round | 26/09/2021 | Santa Tecla FC | - | Once Municipal | 0:1 |  |
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| 12. Round | 03/10/2021 | CD Águila | - | Once Municipal | 1:2 | |
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| 13. Round | 17/10/2021 | Once Municipal | - | Jocoro FC | 2:2 | |
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| 15. Round | 24/10/2021 | Once Municipal | - | Platense Zacatecoluca | 1:1 | ||||
| 16. Round | 30/10/2021 | Once Municipal | - | Alianza | 2:3 | |
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| 17. Round | 02/11/2021 | Once Municipal | - | Luis Ángel Firpo | 1:0 | ||||
| 18. Round | 07/11/2021 | Once Municipal | - | AD Chalatenango | 1:2 | ||||
| 19. Round | 14/11/2021 | FAS | - | Once Municipal | 3:2 | ||||
| 20. Round | 18/11/2021 | Once Municipal | - | Isidro Metapán | 1:1 | ||||
| 21. Round | 21/11/2021 | Atlético Marte | - | Once Municipal | 1:4 | ||||
| 22. Round | 27/11/2021 | Once Municipal | - | Santa Tecla FC | 4:3 |  |
El Salvador