| 1. Round | 19/08/2018 | Real Oviedo | - | Extremadura UD | 1:1 | ||||
| 2. Round | 24/08/2018 | Extremadura UD | - | Deportivo La Coruña | 0:1 |  |
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| 3. Round | 02/09/2018 | Sporting Gijón | - | Extremadura UD | 2:0 |  |
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| 5. Round | 16/09/2018 | Extremadura UD | - | UD Las Palmas | 1:2 | ||||
| 6. Round | 22/09/2018 | Rayo Majadahonda | - | Extremadura UD | 1:4 | ||||
| 7. Round | 30/09/2018 | Extremadura UD | - | Elche CF | 2:2 | ||||
| 8. Round | 06/10/2018 | CD Numancia | - | Extremadura UD | 1:0 | |
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| 10. Round | 21/10/2018 | RCD Mallorca | - | Extremadura UD | 1:1 | |
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| 11. Round | 28/10/2018 | Extremadura UD | - | Albacete | 1:2 | ||||
| 12. Round | 03/11/2018 | Córdoba CF | - | Extremadura UD | 4:2 | |
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| 13. Round | 10/11/2018 | Extremadura UD | - | CA Osasuna | 2:3 | ||||
| 19. Round | 22/12/2018 | Real Zaragoza | - | Extremadura UD | 2:1 |
Spain