| 1. Round | 31/07/2005 | Club San Luis | - | UAG Tecos | 2:1 | ||||
| 2. Round | 06/08/2005 | Deportivo Toluca | - | Club San Luis | 2:1 |  |
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| 3. Round | 14/08/2005 | Club San Luis | - | Jaguares Chiapas | 1:1 | ||||
| 4. Round | 21/08/2005 | Pumas UNAM | - | Club San Luis | 0:0 | |
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| 5. Round | 25/08/2005 | Club San Luis | - | Atlante | 2:2 | ||||
| 6. Round | 28/08/2005 | UANL Tigres | - | Club San Luis | 1:0 | ||||
| 7. Round | 11/09/2005 | Club San Luis | - | Dorados de Sinaloa | 4:1 | ||||
| 8. Round | 18/09/2005 | Santos Laguna | - | Club San Luis | 3:1 | ||||
| 9. Round | 25/09/2005 | Club San Luis | - | Deportivo Guadalajara | 1:2 | ||||
| 10. Round | 29/09/2005 | Club Necaxa | - | Club San Luis | 2:1 | |
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| 11. Round | 02/10/2005 | CF América | - | Club San Luis | 3:1 | ||||
| 14. Round | 30/10/2005 | Club San Luis | - | CF Monterrey | 1:2 |  |
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| 15. Round | 06/11/2005 | CF Pachuca | - | Club San Luis | 0:0 | ||||
| 16. Round | 20/11/2005 | Club San Luis | - | Monarcas Morelia | 2:1 | ||||
| 17. Round | 26/11/2005 | Atlas Guadalajara | - | Club San Luis | 1:0 | |
Uruguay