| 1. Round | 05/08/2007 | UANL Tigres | - | Club San Luis | 0:0 | ||||
| 2. Round | 11/08/2007 | Club San Luis | - | Club Necaxa | 3:2 | ||||
| 3. Round | 18/08/2007 | Club San Luis | - | Cruz Azul | 3:1 | ||||
| 4. Round | 26/08/2007 | Deportivo Toluca | - | Club San Luis | 2:1 |  |
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| 6. Round | 02/09/2007 | CF Pachuca | - | Club San Luis | 4:1 | ||||
| 7. Round | 08/09/2007 | Club San Luis | - | Deportivo Guadalajara | 0:0 | |
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| 8. Round | 16/09/2007 | Atlante | - | Club San Luis | 4:3 | |
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| 9. Round | 22/09/2007 | Club San Luis | - | CF América | 2:1 | |
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| 10. Round | 29/09/2007 | CF Monterrey | - | Club San Luis | 2:3 | ||||
| 11. Round | 06/10/2007 | Club San Luis | - | Puebla FC | 0:3 | ||||
| 12. Round | 13/10/2007 | Jaguares Chiapas | - | Club San Luis | 2:2 | ||||
| 13. Round | 20/10/2007 | Club San Luis | - | Pumas UNAM | 3:2 |  |
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| 14. Round | 27/10/2007 | UAG Tecos | - | Club San Luis | 2:3 | |
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| 15. Round | 01/11/2007 | Club San Luis | - | Monarcas Morelia | 2:1 | ||||
| 16. Round | 04/11/2007 | Atlas Guadalajara | - | Club San Luis | 1:1 | |
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| 17. Round | 10/11/2007 | Club San Luis | - | Santos Laguna | 2:2 |
Uruguay