| 1. Round | 19/01/2008 | Club San Luis | - | UANL Tigres | 1:1 |  |
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| 2. Round | 27/01/2008 | Club Necaxa | - | Club San Luis | 1:1 | ||||
| 3. Round | 02/02/2008 | Cruz Azul | - | Club San Luis | 4:0 | ||||
| 4. Round | 09/02/2008 | Club San Luis | - | Deportivo Toluca | 2:0 | |
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| 5. Round | 14/02/2008 | Veracruz (old) | - | Club San Luis | 1:1 | ||||
| 6. Round | 16/02/2008 | Club San Luis | - | CF Pachuca | 2:1 | |
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| 7. Round | 24/02/2008 | Deportivo Guadalajara | - | Club San Luis | 2:2 | ||||
| 8. Round | 01/03/2008 | Club San Luis | - | Atlante | 2:0 | ||||
| 10. Round | 15/03/2008 | Club San Luis | - | CF Monterrey | 3:1 | ||||
| 13. Round | 06/04/2008 | Pumas UNAM | - | Club San Luis | 2:3 | |
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| 14. Round | 12/04/2008 | Club San Luis | - | UAG Tecos | 1:1 | ||||
| 15. Round | 20/04/2008 | Monarcas Morelia | - | Club San Luis | 1:2 | |
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| 16. Round | 26/04/2008 | Club San Luis | - | Atlas Guadalajara | 0:0 |  |
Uruguay