| 1. Round | 26/07/2008 | Club San Luis | - | Monarcas Morelia | 2:2 | ||||
| 2. Round | 03/08/2008 | CF Pachuca | - | Club San Luis | 2:3 | ||||
| 6. Round | 07/08/2008 | Club San Luis | - | Cruz Azul | 2:1 | ||||
| 4. Round | 17/08/2008 | Atlas Guadalajara | - | Club San Luis | 0:1 | ||||
| 5. Round | 23/08/2008 | Club San Luis | - | UANL Tigres | 1:0 | ||||
| 7. Round | 31/08/2008 | Atlante | - | Club San Luis | 1:0 | ||||
| 8. Round | 13/09/2008 | Club San Luis | - | CF América | 1:2 | ||||
| 9. Round | 21/09/2008 | Pumas UNAM | - | Club San Luis | 0:1 | ||||
| 10. Round | 27/09/2008 | Club San Luis | - | Puebla FC | 1:1 | ||||
| 11. Round | 05/10/2008 | Indios Juárez | - | Club San Luis | 2:3 |  |
Uruguay