1. Round | 08/08/2021 | Vida | - | Lobos UPNFM | 1:1 | ||||
2. Round | 11/08/2021 | Marathón | - | Lobos UPNFM | 5:1 | ||||
3. Round | 15/08/2021 | Lobos UPNFM | - | Honduras Progreso | 3:0 | ||||
4. Round | 22/08/2021 | Lobos UPNFM | - | Platense | 3:0 | ||||
5. Round | 26/08/2021 | Real España | - | Lobos UPNFM | 5:3 | ||||
15. Round | 24/10/2021 | Lobos UPNFM | - | Real España | 1:2 | ||||
16. Round | 27/10/2021 | Real Sociedad | - | Lobos UPNFM | 0:3 | ||||
17. Round | 31/10/2021 | Olimpia | - | Lobos UPNFM | 2:1 |