| 1. Round | 07/02/2022 | River Plate | - | Montevideo Wanderers | 1:1 |  |
|||
| 2. Round | 12/02/2022 | Plaza Colonia | - | River Plate | 0:1 |  |
|||
| 3. Round | 19/02/2022 | River Plate | - | Boston River | 1:2 | |
|||
| 4. Round | 28/02/2022 | River Plate | - | Cerrito | 3:1 | |
|||
| 5. Round | 05/03/2022 | River Plate | - | Cerro Largo | 1:1 | ||||
| 6. Round | 20/03/2022 | River Plate | - | Fénix | 3:1 | ||||
| 8. Round | 10/04/2022 | River Plate | - | Albion | 4:1 | ||||
| 9. Round | 17/04/2022 | Nacional | - | River Plate | 1:1 | |
|||
| 10. Round | 23/04/2022 | River Plate | - | Danubio | 0:0 | |
|||
| 12. Round | 13/05/2022 | River Plate | - | Rentistas | 1:0 | ||||
| 13. Round | 22/05/2022 | Liverpool | - | River Plate | 2:1 | |
|||
| 14. Round | 29/05/2022 | River Plate | - | Peñarol | 0:0 | |
|||
| 15. Round | 03/06/2022 | Montevideo City Torque | - | River Plate | 0:0 |
Uruguay