| 1. Round | 01/08/2021 | AD Chalatenango | - | Platense Zacatecoluca | 2:2 | ||||
| 2. Round | 07/08/2021 | Atlético Marte | - | AD Chalatenango | 0:2 | ||||
| 3. Round | 11/08/2021 | AD Chalatenango | - | Alianza | 2:1 | ||||
| 4. Round | 15/08/2021 | Santa Tecla FC | - | AD Chalatenango | 1:1 | ||||
| 6. Round | 26/08/2021 | CD Águila | - | AD Chalatenango | 2:1 | ||||
| 7. Round | 29/08/2021 | AD Chalatenango | - | Once Municipal | 1:2 | ||||
| 8. Round | 11/09/2021 | Jocoro FC | - | AD Chalatenango | 3:1 | ||||
| 9. Round | 16/09/2021 | AD Chalatenango | - | FAS | 1:2 | ||||
| 10. Round | 19/09/2021 | AD Chalatenango | - | Municipal Limeño | 1:1 |  |
El Salvador