| 2. Round | 31/07/2021 | FK Pohronie | - | MFK Zemplín Michalovce | 2:0 | ||||
| 12. Round | 23/10/2021 | FK Pohronie | - | Spartak Trnava | 0:2 | ||||
| 14. Round | 06/11/2021 | FK Pohronie | - | MŠK Žilina | 1:2 | ||||
| 17. Round | 04/12/2021 | FC DAC 1904 | - | FK Pohronie | 2:0 | ||||
| 18. Round | 11/12/2021 | FK Pohronie | - | FK Senica | 0:1 | ||||
| 19. Round | 18/12/2021 | FK Pohronie | - | Tatran Liptovský Mikuláš | 2:2 | ||||
| 20. Round | 12/02/2022 | AS Trenčín | - | FK Pohronie | 3:0 | ||||
| 21. Round | 19/02/2022 | FK Pohronie | - | Slovan Bratislava | 3:4 |
Slovakia