| 5. Round | 15/09/2021 | Dinamo Zagreb II | - | NK Opatija | 2:1 |  |
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| 6. Round | 18/09/2021 | NK Opatija | - | NK Solin | 1:1 | ||||
| 7. Round | 26/09/2021 | NK Croatia Zmijavci | - | NK Opatija | 3:0 | ||||
| 8. Round | 02/10/2021 | NK Osijek II | - | NK Opatija | 0:2 | ||||
| 9. Round | 16/10/2021 | NK Opatija | - | NK Varaždin | 2:2 | |
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| 10. Round | 23/10/2021 | NK Rudeš | - | NK Opatija | 3:0 | ||||
| 11. Round | 30/10/2021 | NK Opatija | - | NK Jarun | 0:1 | ||||
| 12. Round | 05/11/2021 | NK Sesvete | - | NK Opatija | 2:1 | ||||
| 13. Round | 20/11/2021 | NK Opatija | - | NK Dugopolje | 0:2 | ||||
| 14. Round | 27/11/2021 | NK Dubrava | - | NK Opatija | 1:0 | ||||
| 15. Round | 04/12/2021 | NK Opatija | - | HNK Orijent Rijeka | 0:1 | ||||
| 16. Round | 12/02/2022 | NK Opatija | - | HNK Cibalia | 2:1 | ||||
| 18. Round | 26/02/2022 | NK Opatija | - | NK Kustošija | 2:1 | ||||
| 19. Round | 06/03/2022 | NK BSK Bijelo Brdo | - | NK Opatija | 4:1 | ||||
| 20. Round | 12/03/2022 | NK Opatija | - | Dinamo Zagreb II | 0:0 | |
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| 22. Round | 02/04/2022 | NK Opatija | - | NK Croatia Zmijavci | 2:1 | ||||
| 23. Round | 09/04/2022 | NK Opatija | - | NK Osijek II | 1:2 | ||||
| 24. Round | 16/04/2022 | NK Varaždin | - | NK Opatija | 4:0 |
Croatia