| 1. Round | 12/09/2021 | KS Kastrioti | - | Dinamo Tiranë | 0:2 | ||||
| 2. Round | 19/09/2021 | FK Kukësi | - | KS Kastrioti | 3:1 | ||||
| 3. Round | 25/09/2021 | KS Kastrioti | - | KF Tiranë | 1:1 | ||||
| 4. Round | 02/10/2021 | Egnatia Rrogozhine | - | KS Kastrioti | 2:1 | ||||
| 5. Round | 16/10/2021 | KS Kastrioti | - | KF Skënderbeu | 2:0 | ||||
| 6. Round | 23/10/2021 | KS Kastrioti | - | KF Laçi | 0:1 | ||||
| 7. Round | 31/10/2021 | KF Teuta Durrës | - | KS Kastrioti | 1:1 |  |
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| 8. Round | 07/11/2021 | KS Kastrioti | - | FK Partizani | 0:2 | ||||
| 9. Round | 20/11/2021 | FK Vllaznia | - | KS Kastrioti | 3:1 | ||||
| 10. Round | 28/11/2021 | Dinamo Tiranë | - | KS Kastrioti | 1:0 | ||||
| 11. Round | 04/12/2021 | KS Kastrioti | - | FK Kukësi | 1:6 | |
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| 12. Round | 07/12/2021 | KF Tiranë | - | KS Kastrioti | 3:0 | ||||
| 13. Round | 12/12/2021 | KS Kastrioti | - | Egnatia Rrogozhine | 1:0 | ||||
| 14. Round | 18/12/2021 | KF Skënderbeu | - | KS Kastrioti | 2:1 | ||||
| 15. Round | 22/12/2021 | KF Laçi | - | KS Kastrioti | 2:0 |
Croatia