| 2. Round | 12/09/2021 | AEK Larnaca | - | Omonia Nikosia | 2:1 | ||||
| 3. Round | 20/09/2021 | Omonia Nikosia | - | Doxa Katokopias | 2:1 |  |
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| 4. Round | 26/09/2021 | Omonia Nikosia | - | Paphos FC | 1:1 | ||||
| 5. Round | 03/10/2021 | Olympiakos Nikosia | - | Omonia Nikosia | 1:0 | ||||
| 6. Round | 17/10/2021 | Omonia Nikosia | - | Apollon Limassol | 1:0 | |
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| 7. Round | 25/10/2021 | PAEEK | - | Omonia Nikosia | 1:0 | ||||
| 9. Round | 07/11/2021 | Ethnikos Achna | - | Omonia Nikosia | 0:2 | ||||
| 10. Round | 21/11/2021 | Omonia Nikosia | - | Aris Limassol | 3:0 | ||||
| 12. Round | 05/12/2021 | AEL Limassol | - | Omonia Nikosia | 0:1 | ||||
| 13. Round | 13/12/2021 | Omonia Nikosia | - | AEK Larnaca | 1:1 | ||||
| 14. Round | 19/12/2021 | Doxa Katokopias | - | Omonia Nikosia | 2:1 |  |
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| 1. Round | 22/12/2021 | Omonia Nikosia | - | AEL Limassol | 1:0 | |
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| 11. Round | 26/12/2021 | APOEL Nikosia | - | Omonia Nikosia | 4:2 | ||||
| 16. Round | 10/01/2022 | Omonia Nikosia | - | Olympiakos Nikosia | 1:0 | ||||
| 17. Round | 16/01/2022 | Apollon Limassol | - | Omonia Nikosia | 2:0 |
Cyprus